Evaluation of Antacid Activity of Garcinia Indica Fruit Rind by a Modified Artificial Stomach Model

The present study investigates the antacid effect of the aqueous extract of the fruit rind of Garcinia indica (GIE) by using a modified artificial stomach model. The pH of GIE (400 mg/kg and 800 mg/kg) and its neutralizing effect on artificial gastric acid was determined and compared with water and the active control sodium bicarbonate. A modified model of Vatier’s artificial stomach was used to determine the duration of consistent neutralization of the artificial gastric acid. The neutralization capacity in vitro was determined with the classical titration method of Fordtran’s model. All treatments including GIE 400 mg/kg, GIE 800 mg/kg and sodium bicarbonate showed significant acid neutralizing effects when compared with water. The duration for consistent neutralization and antacid capacities of GIE 400 mg/kg and 800 mg/kg were significantly higher than that of water. GIE (400 mg/kg and 800 mg/kg) was consistently active in the artificial stomach model and possesses potent antacid effects.