Mast cells promote lung vascular remodeling in pulmonary hypertension
نویسندگان
چکیده
Institute of Physiology, Charité – Universitätsmedizin Berlin, Germany; The Keenan Research Centre at the Li Ka Shing Knowledge Institute of St. Michael ́s Hospital, Toronto, ON; Department of Anesthesiology, German Heart Institute Berlin, Germany; Genolyze, Turku, Finland; Center for Experimental Medicine, Medical School, University of Cologne, Germany; University of Giessen Lung Center, Germany; Max-Planck-Institute of Heart and Lung Research, Bad Nauheim, Germany; Department of Surgery, University of Toronto, ON.
منابع مشابه
Prevention of mast cell degranulation by disodium cromoglycate attenuates the development of hypoxic pulmonary hypertension in rats exposed to chronic hypoxia.
BACKGROUND Chronic hypoxia induces lung vascular remodeling, which results in pulmonary hypertension. Vascular remodeling is associated with collagenolysis and activation of matrix metalloproteinases (MMPs). One of the possible sources of MMPs in hypoxic lung are mast cells. OBJECTIVE The role of lung mast cell collagenolytic activity in hypoxic pulmonary hypertension was tested by the inhibi...
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Hypoxic pulmonary hypertension (HPH) is a syndrome characterized by the increase of pulmonary vascular tone and the structural remodeling of peripheral pulmonary arteries. Mast cells have an important role in many inflammatory diseases and they are also involved in tissue remodeling. Tissue hypoxia is associated with mast cell activation and the release of proteolytic enzymes, angiogenic and gr...
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A proliferation of mast cells around the small pulmonary blood vessels and the alveolar septae has been noted in models of pulmonary hypertension, and in plexiform lesions of pulmonary arterial hypertension (PAH) in patients. Here, we hypothesize that total mast cell numbers and activation are increased in PAH and that they contribute to vascular remodeling through cellular and soluble proangio...
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Over past years, a critical role for the immune system and, in particular, for mast cells in the pathogenesis of pulmonary hypertension (PH) has emerged. However, the way in which mast cells promote PH is still poorly understood. Here, we investigated the mechanisms by which mast cells may contribute to PH, specifically focusing on the interaction between the innate and adaptive immune response...
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Pulmonary arterial hypertension (PAH) is a progressive disease defined by a chronic elevation in pulmonary arterial pressure with extensive pulmonary vascular remodeling and perivascular inflammation characterized by an accumulation of macrophages, lymphocytes, dendritic cells, and mast cells. Although the exact etiology of the disease is unknown, clinical as well as preclinical data strongly i...
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