[Coumarins: interaction with vitamin K antagonists and safety of tonka bean].

نویسندگان

  • Eduardo López-Briz
  • Amparo Vázquez-Polo
چکیده

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[Established anticoagulants in secondary haemostasis--Vitamin K antagonists, heparins].

In respect to the actual discussion of new anticoagulants in secondary haemostasis, we will give a short review on established oral anticoagulation with vitamin K antagonists and parenteral anticoagulation by use of heparin. The different coumarin derivatives phenprocoumon, warfarin, and acenocoumarol are compared concerning to the management and influence of pharmacogenetic and pharmacokinetic...

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Rapid Detection of Vanilla Bean Extract Adulteration with Tonka Bean Extract with No Chromatography or Sample Preparation

The production of vanilla beans is quite expensive, since it is a very labor intensive process and harvesting takes place two to three years after planting. Due to this, the price of natural vanilla bean extract is quite expensive. It is quite often adulterated with cheaper tonka bean extract, which smells and tastes like vanilla bean extract due to the presence of a compound called coumarin1. ...

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Glucosides of coumarinic and o-coumaric acids in the tonka bean.

The beta-glucosides of coumarinic and o-coumaric acids were detected in extracts of cotyledons, exocarps, and seedling leaves of the tonka bean. The existence of these compounds and the presence of a beta-glucosidase having specificity for coumarinyl glucoside suggest that the tonka bean synthesizes coumarin by a pathway similar to the one found in sweetclover.

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[Safety of tonka bean].

and Materials in Contact with Food on a request from the European Commission on Coumarin in flavourings and other food ingredients with flavouring properties.

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Assessing patients' anticoagulation preferences for the treatment of cancer-associated thrombosis using conjoint methodology.

Low molecular weight heparins have demonstrated superiority over coumarins in the extended treatment of cancer-associated thrombosis and are recommended as first-line therapy in clinical guidelines. Non-vitamin K oral antagonists are yet to be evaluated against low molecular weight heparin for this indication. Nevertheless, a perception that patients favor oral anticoagulants over injections ma...

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عنوان ژورنال:
  • Gaceta sanitaria

دوره 26 2  شماره 

صفحات  -

تاریخ انتشار 2012