Enantioselective nitro-Michael reactions catalyzed by short peptides on water.

نویسندگان

  • Matthias Freund
  • Sebastian Schenker
  • Svetlana B Tsogoeva
چکیده

Simple unmodified N-proline-based di- and tripeptides in combination with sodium hydroxide additive catalyze the asymmetric Michael reaction of ketones with nitroolefins to furnish the corresponding gamma-nitroketones with up to 99% yield, 99:1 dr and 70% ee at room temperature and on water without any organic cosolvent.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 7 20  شماره 

صفحات  -

تاریخ انتشار 2009