Lippia sidoides Essential Oil Encapsulation by Angico Gum/Chitosan Nanoparticles
نویسندگان
چکیده
Nanoparticulas de quitosana (CH) e goma do angico (AG), dopadas com óleo essencial de Lippia sidoides (Ls) foram preparadas e caracterizadas em relação às suas composições, distribuição de tamanho de partículas, estabilidade térmica, bem como as liberações in vitro e in vivo. Os dados obtidos revelaram que as nanopartículas preparadas usando razões Ls:AG variando de 1:2 a 1:20, apresentaram dopagens na faixa de 3,3 a 7,7%, com eficiência de encapsulação entre 16,0 e 77,8%. Os tamanhos de partículas ficaram na faixa de 10-60 nm, com distribuições independentes do teor de óleo incorporado. FTIR revelou a presença de timol, principal componente de Ls. Análises de TGA e DSC mostraram que a incorporação de óleo na matriz resulta em nanopartículas de menor estabilidade térmica. A amostra Ls:AG = 1:10 apresentou um perfil de liberação in vitro mais lento que as demais, exibindo, porém, nos bioensaios, uma maior mortalidade larval.
منابع مشابه
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