Early Changes in Phosphatidylcholine Metabolism in Human Acute Promyelocytic Leukemia Cells Stimulated to Differentiate by Phorbol
نویسنده
چکیده
The HL-60 leukemia cell line derived from a human acute promyelocytic leukemia is stimulated to differentiate into macrophages within 24-48 hr after exposure to the phorbol ester. 1 2-O-tetradecanoylphorbol-1 3-acetate (TPA). We studied early alterations (within 90 mm of exposure to TPA) in phosphatidylcholine metabolism in HL-60 cells and found that phosphatidylcholine synthesis by methylation of phosphatidylethanolamine was inhibited in a dose-dependent fashion. In contrast. synthesis of phosphatidylcholine
منابع مشابه
Early changes in phosphatidylcholine metabolism in human acute promyelocytic leukemia cells stimulated to differentiate by phorbol ester.
The HL-60 leukemia cell line derived from a human acute promyelocytic leukemia is stimulated to differentiate into macrophages within 24-28 hr after exposure to the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA). We studied early alterations (within 90 min of exposure to TPA) in phosphatidylcholine metabolism in HL-60 cells and found that phosphatidylcholine synthesis by methylation ...
متن کاملEarly Changes in Phosphatidylcholine Metabolism in Human Acute Promyelocytic Leukemia Cells
The HL-60 leukemia cell line derived from a human acute promyelocytic leukemia is stimulated to differentiate into macrophages within 24-48 hr after exposure to the phorbol ester. 1 2-O-tetradecanoylphorbol-1 3-acetate (TPA). We studied early alterations (within 90 mm of exposure to TPA) in phosphatidylcholine metabolism in HL-60 cells and found that phosphatidylcholine synthesis by methylation...
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