Isolation and characterization of a second thioredoxin in D. melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2
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چکیده
§ Current address: Epidemiology and Public Health, Yale University School of Medicine, LEPH612, 60 College Street, New Haven, CT 06520, USA To whom correspondence should be addressed: R. Heiner Schirmer or Holger Bauer, Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany, Phone ++49 6221 544175/-88, Fax ++49 6221 545586, email: [email protected] or [email protected]
منابع مشابه
The Human Thioredoxin System: Modifications and Clinical Applications
The thioredoxin system, comprising thioredoxin (Trx), thioredoxin reductase (TrxR) and NADPH, is one of the major cellular antioxidant systems, implicated in a large and growing number of biological functions. Trx acts as an oxidoreductase via a highly conserved dithiol/disulfide motif located in the active site ( Trp-Cys-Gly-Pro- Cys-Lys-). Different factors are involved in the regulation of T...
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