Detecting reperfusion myocardial hemorrhage with T2 and T2* maps at 1.5T
نویسندگان
چکیده
Methods Canines (n = 9) were subjected to a 3-hour occlusion of the LAD followed by reperfusion. Serial CMR studies (1.5T Siemens Espree) were performed post-reperfusion on days 2, 5 and 7. Short-axis images of the entire LV (resolution = 1.1x1.1x8mm3) were obtained using T2-prepared SSFP (T2-preparation= 0, 24 and 55ms), multi gradient-echo (TE=3.43ms, 6.42ms, 9.41ms, 12.40ms, 15.39ms and 18.38ms) and PSIR LateEnhancement (LE-PSIR) imaging. T2 and T2* maps were computed from T2-prepared and gradient-echo acquisitions. Hemorrhagic infarctions (MH+) were determined by the presence of hypointense territories on T2* maps within the infarcted zones identified from LE-PSIR images. In the MH+ group, manually drawn ROIs on the T2* maps around the hemorrhagic cores and remote territories were copied to the T2 maps. In non-hemorrhagic infarctions (MH-), manually drawn ROIs on LE-PSIR images around the infarcted zones and remote territories were copied to T2 and T2* maps. T2 and T2* values from the MH+, MH-
منابع مشابه
Contribution of reperfusion hemorrhage to T2 and T2* CMR in the quantification of hemorrhage extent and area-at-risk after acute myocardial infarction
Background In acute myocardial infarction (AMI), reperfusion injury is often associated with hemorrhage and microvascular obstruction (MVO), which are independent predictors of poor patient outcomes. T2 and T2* cardiovascular magnetic resonance (CMR) approaches have been instrumental in detecting hemorrhage; however, the relative sensitivity of each of these measures remains to be investigated....
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