Fetal Hemoglobin with Abnormal ‘ Y . Polypeptide Chains : Hemoglobin Warren

By T. H. J. HUISMAN, A. M. Dozy, B. E. HORTON AND J. B. WILsON T HE EXISTENCE of variants of normal human fetal hemoglobin ( HbFor a2y2 ) has been suggested in different reports in the literature. Variants of fetal hemoglobin with abnormal a-polypeptide chains have been described5 ”5 and some are well characterized.’0 Only one abnormality, namely the electrophoretically fast moving hemoglobin variant Hb F oma, has been identified as being composed of normal a-chains and abnormal y-chains.’3 Other possible variants include Hh-Alexandra,2’#{176}”6 the fetal hemoglobin of the Texas type12 and Hb-Cypnis I; these hemoglobin types, however, are too inadequately characterized to be classified definitely under 1 of these 2 groups of Hh-F variants. In this paper we will report studies of an abnormal hemoglobin fraction ( designated as Hb WTarren ) which was found to be present in the cord blood sample cf a healthy Negro newborn. The isolated hemoglobin was characterized by various analytical procedures and was found to be composed of normal a-polypeptide chains and abnormal y-polypeptide chains.