TRANSLATIONAL PHYSIOLOGY Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na /H exchanger proteins
نویسندگان
چکیده
Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na /H exchanger proteins Silvia Muro, Madalina Mateescu, Christine Gajewski, Mary Robinson, Vladimir R. Muzykantov, and Michael Koval Institute for Environmental Medicine, Department of Pharmacology and Targeted Therapeutics Program of the Institute of Translational Medicine and Therapeutics, Department of Physiology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania; and Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia
منابع مشابه
Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins.
Targeting nanocarriers (NC) loaded by antioxidant enzymes (e.g., catalase) to endothelial cell adhesion molecules (CAM) alleviates oxidative stress in the pulmonary vasculature. However, antioxidant protection is transient, since CAM-targeted catalase is internalized, delivered to lysosomes, and degraded. To design means to modulate the metabolism and longevity of endothelial cell (EC)-targeted...
متن کاملControl of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na/H Exchanger (NHE) proteins
Targeting nanocarriers (NCs) loaded by antioxidant enzymes (e.g., catalase) to endothelial cell adhesion molecules (CAMs) alleviates oxidative stress in the pulmonary vasculature. However, antioxidant protection is transient, since CAM-targeted catalase is internalized, delivered to lysosomes and degraded. To design means to modulate the metabolism and longevity of endothelial cell (EC) targete...
متن کاملSlow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress.
Nanotechnologies promise new means for drug delivery. ICAM-1 is a good target for vascular immunotargeting of nanoparticles to the perturbed endothelium, although endothelial cells do not internalize monomeric anti-ICAM-1 antibodies. However, coupling ICAM-1 antibodies to nanoparticles creates multivalent ligands that enter cells via an amiloride-sensitive endocytic pathway that does not requir...
متن کاملDistinct Subcellular Trafficking Resulting from Monomeric vs Multimeric Targeting to Endothelial ICAM-1: Implications for Drug Delivery
Ligand-targeted, receptor-mediated endocytosis is commonly exploited for intracellular drug delivery. However, cells-surface receptors may follow distinct endocytic fates when bound by monomeric vs multimeric ligands. Our purpose was to study this paradigm using ICAM-1, an endothelial receptor involved in inflammation, to better understand its regulation and potential for drug delivery. Our pro...
متن کاملICAM‐1‐targeted nanocarriers attenuate endothelial release of soluble ICAM‐1, an inflammatory regulator
Targeting of drug nanocarriers (NCs) to intercellular adhesion molecule-1 (ICAM-1), an endothelial-surface protein overexpressed in many pathologies, has shown promise for therapeutic delivery into and across this lining. Yet, due to the role of ICAM-1 in inflammation, the effects of targeting this receptor need investigation. Since ICAM-1 binding by natural ligands (leukocyte integrins) result...
متن کامل