EYcacy of nasal continuous positive airway pressure therapy in chronic heart failure: importance of underlying cardiac rhythm

Background—Some previous reports have indicated beneficial cardiac eVects of nasal continuous positive airway pressure (NCPAP) in patients with severe congestive heart failure (CHF), but others have reported deleterious cardiac eVects, particularly among patients in atrial fibrillation (AF). The aim of this study was to determine if diVerences in cardiac rhythm influence the acute cardiac response to NCPAP. Methods—Eleven consecutive patients with CHF were recruited, six in atrial fibrillation (AF) and five with sinus rhythm (SR). Cardiac index was measured during awake NCPAP application by the thermodilution technique during cardiac catheterisation. NCPAP was applied in a randomised sequence at pressures of 0, 5, and 10 cm H2O with three 30 minute applications separated by 20 minute recovery periods without NCPAP. Results—Significant diVerences were found between the AF and SR groups for cardiac index responses to NCPAP (p = 0.004, ANOVA) with a fall in cardiac index in the AF group (p = 0.02) and a trend towards an increase in the SR group (p = 0.10). Similar diVerences were seen between the groups in stroke volume index responses but not in heart rate responses. Changes in systemic vascular resistance were also significantly diVerent between the two groups (p< 0.005, ANOVA), rising in the AF group but falling in the SR group. Conclusions—These data indicate an important eVect of underlying cardiac rhythm on the awake haemodynamic eVects of NCPAP in patients with CHF. (Thorax 1998;53:957–962)