Research Paper ENUMERATION AND STRUCTURAL ASSESSMENT OF MURINE PERITONEAL MACROPHAGES EXPOSED TO CHROMIUM (VI): A PRELIMINARY STUDY
نویسنده
چکیده
Heavy metals have significant importance in altering the immune response. Chromium is found in the environment commonly in trivalent, Cr (III), and hexavalent, Cr (VI), forms. The reduction of Cr (VI) to Cr (III) results in the formation of reactive intermediates (ROS) that contribute to the cytotoxicity and genotoxicity. In this study mice were treated with chromium (VI) oxide (24 mg /kg body weight in 1 ml water / day for 21 days). Macrophage study was done after Iyengar et al. 1985. In treated group significant numbers of peritoneal macrophages were found to be pyknotic. The cellular death was confirmed by membrane blebbing and membrane rupture. Percentages of cells showing membrane blebbing was increased significantly after treatment. The result indicated that Cr (VI) induced toxicity may affect macrophage mediated immunity. So macrophage activation during heavy metal mediated reaction is an interesting area to be explored in future researches.
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