Stabilized -Catenin in Thymic Epithelial Cells Blocks Thymus Development and Function
نویسندگان
چکیده
منابع مشابه
Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.
Thymic T cell development is dependent on a specialized epithelial microenvironment mainly composed of cortical and medullary thymic epithelial cells (TECs). The molecular programs governing the differentiation and maintenance of TECs remain largely unknown. Wnt signaling is central to the development and maintenance of several organ systems but a specific role of this pathway for thymus organo...
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catenin is a critical mediator of the Wnt canonical pathway for multiple cellular responses. Using transgenic mice, loss or activation of β-catenin has been studied in multiple tissues to elucidate its role in vivo. In this editorial, we focus on recent findings examining the involvement of β-catenin in cancer initiation and progression of epithelial tissues in thymus and prostate. β-catenin in...
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