Comparing the oropharyngeal colonization density of Kingella kingae between asymptomatic carriers and children with invasive osteoarticular infections.
نویسندگان
چکیده
Colonization of the oropharynx by Kingella kingae is currently considered to be a prerequisite for later development of invasive infections. However, the oropharyngeal K. kingae DNA bacterial load in children with osteoarticular infections caused by this microorganism is not different than that of asymptomatic carriers.
منابع مشابه
Small risk of osteoarticular infections in children with asymptomatic oropharyngeal carriage of Kingella kingae.
The aim of this study was to evaluate the absolute risk for children younger than 4 years of age with asymptomatic oropharyngeal carriage of Kingella kingae to sustain an osteoarticular infection. The rate of K. kingae carriage in the oropharyngeal mucosa was 9% among healthy children, and the risk for an asymptomatic carrier to develop an osteoarticular infection due to K. Kingae was estimated...
متن کاملDetection of Kingella kingae osteoarticular infections in children by oropharyngeal swab PCR.
OBJECTIVE The purpose of this study was to investigate if oropharyngeal swab polymerase chain reaction (PCR) could predict osteoarticular infection (OAI) due to Kingella kingae in young children. METHODS One hundred twenty-three consecutive children aged 6 to 48 months presenting with atraumatic osteoarticular complaints were prospectively studied. All had a clinical evaluation, imaging, and ...
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Increasing recognition of Kingella kingae as an important pathogen of early childhood in recent years has elicited interest in the study of the asymptomatic carriage of the organism, its dissemination in the human population, and the role played by colonization of the upper respiratory tract in the pathogenesis of K. kingae invasion of the skeletal system and the endocardium. Research has revea...
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The bacterium Kingella kingae is a species of Gram-negative coccobacillus usually found in the oropharynx. This is an emerging pathogen reported to cause bacteraemia, endocarditis, and osteoarticular infections in children and endocarditis in the immunocompromised adult. However, there are few cases of isolated joint infections reported in the immunocompetent adult. Due to specific isolation te...
متن کاملKingella kingae: carriage, transmission, and disease.
Kingella kingae is a common etiology of pediatric bacteremia and the leading agent of osteomyelitis and septic arthritis in children aged 6 to 36 months. This Gram-negative bacterium is carried asymptomatically in the oropharynx and disseminates by close interpersonal contact. The colonized epithelium is the source of bloodstream invasion and dissemination to distant sites, and certain clones s...
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ورودعنوان ژورنال:
- The Pediatric infectious disease journal
دوره 32 4 شماره
صفحات -
تاریخ انتشار 2013