Protease-catalysed Direct Asymmetric Mannich Reaction in Organic Solvent
نویسندگان
چکیده
We reported the first enzyme-catalysed, direct, three-component asymmetric Mannich reaction using protease type XIV from Streptomyces griseus (SGP) in acetonitrile. Yields of up to 92% with enantioselectivities of up to 88% e.e. and diastereoselectivities of up to 92:8 (syn:anti) were achieved under the optimised conditions. This enzyme's catalytic promiscuity expands the application of this biocatalyst and provides a potential alternative method for asymmetric Mannich reactions.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2012