[Hydroxy(tosyloxy)iodo]benzene Mediated α-Azidation of Ketones
نویسندگان
چکیده
Reaction of various ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment of the α-tosyloxy ketones thus generated in situ with NaN3 offers a one-pot procedure for the synthesis of α-azido ketones. The HTIB used in this conversion may also be generated in situ by using iodosobenzene in combination with p-toluenesulphonic acid.
منابع مشابه
Application of [Hydroxy(tosyloxy)iodo]benzene in the Wittig- Ring Expansion Sequence for the Synthesis of β-Benzocyclo- alkenones from α-Benzocycloalkenones
The conversion of α-benzocycloalkenones to homologous β-benzocycloalkenones containing six, seven and eight-membered rings is reported. This was accomplished via a Wittig olefination-oxidative rearrangement sequence using [hydroxy(tosyloxy)iodo]-benzene (HTIB) is the oxidant, that enables the synthesis of regioisomeric pairs of methyl-substituted β-benzocycloalkenones. The incorporation of carb...
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