The Shc binding site of the β c subunit of the GM - CSF / IL - 3 / IL - 5 receptors is a negative regulator of hematopoiesis
نویسندگان
چکیده
1The Cytokine Receptor Laboratory, Division of Human Immunology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, South Australia 5000 Australia; 2Cell Growth and Differentiation Laboratory, Division of Human Immunology, Institute of Medical and Veterinary Science, Hanson Institute; 3Department of Medicine, University of Adelaide, South Australia 5000 Australia; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia and Amgen Inc., Thousand Oaks, CA 91320-1799
منابع مشابه
The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis.
Tyrosine and serine phosphorylation of the common beta chain (beta(c)) of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors is widely viewed as a general mechanism that provides positive inputs by coupling the receptor to signaling pathways that stimulate several cellular functions. We show here that despite the known action of Tyr577 in bet...
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