The Association Between Low Back Pain and Composition of IgG Glycome
نویسندگان
چکیده
Low back pain (LBP) is a common debilitating condition which aetiology and pathogenesis are poorly understood. We carried out a first so far analysis of associations between LBP and plasma IgG N-glycome in a sample of 4511 twins from TwinsUK database assessed for LBP, lumbar disc degeneration (LDD) as its possible cause, and IgG-glycan levels. Using weighted correlation network analysis, we established a correlation between LBP and glycan modules featured by glycans that either promote or block antibody-dependent cell-mediated cytotoxicity (ADCC). The levels of four glycan traits representing two of those modules were statistically significantly different in monozygotic twins discordant for LBP. Also, the trend to higher prevalence of systemic inflammatory disorders was shown for twins with low level of fucosylated glycans and high level of non-fucosylated glycans. Core fucosylation of IgG is a "safety switch" reducing ADCC, thus our results suggest the involvement of ADCC and associated inflammation in pathogenesis of LBP. No correlation between LDD scores and glycans was found assuming that the inflammation may not be a part of LDD. These data provide a new insight into understanding the complex pathophysiology of LBP and suggest glycan levels as a possible biomarker for inflammation-related subtypes of LBP.
منابع مشابه
valence of low Back Pain and Its Association with Anxiety and Depression in Male and Female Nurses
Introduction: The present study examined the prevalence of back pain and its association with anxiety and depression in nurses working in affiliated hospitals to social security organization in Isfahan city. Research Method: The design of this research was descriptive-correlation and its population consisted of 815 nurses working in Shariati (510 subjects) and Gharazy hospitals (305 subjects...
متن کاملThe effect of back pain on body posture, Somatotype and body composition in women
Background: Low back pain causes movement and occupational restrictions in women. The aim of this study was to compare women with and without low back pain and its relationship with body type, muscle percentage and fat. Methods: The statistical population consisted of women with low back pain (28 people, 30 to 60 years old) were randomly selected and 28 people were selected as healthy or contr...
متن کاملThe prevalence of low back pain and its association with some demographic factors in the city of Kerman
The prevalence of low back pain(BPP) ios high.in this study the prevalence of low back pain(LBP) was determined in Kerman province:for this purpose 1000 subjects were selected by systematic random sampling.the data were collected by using a questionnaire and face to face interview.as pain is a subjective phenomena,the self-report of LBP was the criteria for pain or absence of pain.for data ana...
متن کاملEffects of allergic diseases and age on the composition of serum IgG glycome in children
It is speculated that immunoglobulin G (IgG) plays a regulatory role in allergic reactions. The glycans on the Fc region are known to affect IgG effector functions, thereby possibly having a role in IgG modulation of allergic response. This is the first study investigating patients' IgG glycosylation profile in allergic diseases. Subclass specific IgG glycosylation profile was analyzed in two c...
متن کاملAssociation of Systemic Lupus Erythematosus With Decreased Immunosuppressive Potential of the IgG Glycome
OBJECTIVE Glycans attached to the Fc portion of IgG are important modulators of IgG effector functions. Interindividual differences in IgG glycome composition are large and they associate strongly with different inflammatory and autoimmune diseases. IKZF1, HLA-DQ2A/B, and BACH2 genetic loci that affect IgG glycome composition show pleiotropy with systemic lupus erythematosus (SLE), indicating a...
متن کامل