LKB1 inhibition of NF-kB in B cells prevents T folicullar helper cell differentiation and germinal center formation
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منابع مشابه
LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.
T-cell-dependent antigenic stimulation drives the differentiation of B cells into antibody-secreting plasma cells and memory B cells, but how B cells regulate this process is unclear. We show that LKB1 expression in B cells maintains B-cell quiescence and prevents the premature formation of germinal centers (GCs). Lkb1-deficient B cells (BKO) undergo spontaneous B-cell activation and secretion ...
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