Provocative testing of human growth hormone release in short statured children.
نویسندگان
چکیده
We have studied the combined use of two procedures, i.e, L-Dopa stimulation and exercise stimulation as provocative tests of hGH release in establishing the diagnosis of hGH deficiency in 30 short statured children. This combination was found to be a simple, reliable and practical regimen for routine use as an outdoor diagnostic procedure. Our initial experience with the “Cold pressor test”, a new test of hGH stimulation is also reported (JPMA 37:256 ,1987).
منابع مشابه
The Evaluation and Followup of Children Referred to Pediatric Endocrinologists for Short Stature
Objective. To characterize the pediatric endocrinologists' evaluation and followup of short-statured patients. Study Design. Observational study of 21,548 short-statured children (April 1996 to December 1999). Baseline demographics, laboratory testing, height standard deviation score (SDS), target height, and height relative to target height were analyzed at initial and return visits with the s...
متن کاملMethods in determining growth hormone concentrations: an immunofunctional assay.
Actual measurement of growth hormone (GH) levels in children suspected of having GH deficiency can confirm this diagnosis. However, there currently is no standard for the test. Although there is general agreement that in a short-statured child, a value of <10 microg/L in response to an appropriate provocative test indicates the possible need for GH replacement therapy, there is no agreement on ...
متن کاملSelecting short-statured children needing growth hormone testing: Derivation and validation of a clinical decision rule
BACKGROUND Numerous short-statured children are evaluated for growth hormone (GH) deficiency (GHD). In most patients, GH provocative tests are normal and are thus in retrospect unnecessary. METHODS A retrospective cohort study was conducted to identify predictors of growth hormone (GH) deficiency (GHD) in children seen for short stature, and to construct a very sensitive and fairly specific p...
متن کاملIsotopic and nonisotopic assays for measuring somatotropin compared: re-evaluation of cutoff value in provocative tests.
Measurement of human growth hormone (hGH; somatotropin) concentrations in serum after provocative tests is crucial for diagnosing deficiencies in production of this hormone. Serum hGH can be measured by various immunoassays, isotopic and nonisotopic, with monoclonal or polyclonal antibodies: a cutoff value of 10 micrograms/L after provocative testing is usually used to distinguish normal from h...
متن کاملEarly diagnosis and treatment referral of children born small for gestational age without catch-up growth are critical for optimal growth outcomes
Approximately 10% of children born small for their gestational age (SGA) fail to show catch-up growth and may remain short-statured as adults. Despite treatment guidelines for children born SGA that recommend referral for growth hormone (GH) therapy evaluation and initiation by ages 2 to 4 years, the average age of GH treatment initiation is typically much later, at ages 7 to 9 years. Delayed r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- JPMA. The Journal of the Pakistan Medical Association
دوره 37 10 شماره
صفحات -
تاریخ انتشار 1987