RAPID COMMUNICATION Recombinant Thrombopoietin Induces Rapid Protein Tyrosine Phosphorylation
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چکیده
A cDNA for the thrombopoietin has been cloned by several groups. The recombinant thrombopoietin has been reported to stimulate the megakaryocytopoiesis and thrombopoiesis. Little is known regarding the molecular basis of its effects. To elucidate the molecular mechanism involved in signal transduction, we have investigated the effects of thrombopoietin on platelet tyrosine phosphorylation. We report here that thrombopoietin induced timeand dose-dependent tyrosine phosphorylation of several proteins including Janus
منابع مشابه
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