Flow cytometry to identify bone-marrow relapse in blastic plasmacytoid dendritic cell neoplasm: a case report
نویسندگان
چکیده
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare acute leukemia subtype characterized by clonal expansion of dendritic-lineage cells.1 These cells are identified immunophenotypically by weak CD45 expression and coexpression of the CD4 and CD56 antigens in the absence of other lineage-specific markers.2,3 Previously known as blastic natural killer (NK)-cell lymphoma or CD4+/CD56+ hematodermic neoplasm, it is currently classified by the World Health Organization (WHO) as a distinct entity, under the acute myeloid leukemia (AML) and related precursor neoplasm group.4 Few studies have assessed the incidence of BPDCN in the general population. The limited existing data suggest an extremely low overall incidence, representing 0.44% of all hematological malignancies3,5 and 0.7% of cutaneous
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Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematodermic myeloid malignancy that is known to be derived from plasmacytoid dendritic cells which are characterized by expression of CD4, CD56, and more specific markers such as CD123. Here, the authors present three cases of BPDCN diagnosed in the past two years and address different available diagnostic modalities such as morpho...
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