Effect of dimethylsulfoxide on transdermal patches of azelnidipine

In the present study, is to development of Azelnidipine (AZP) transdermal patches and to study the effect of Dimethyl sulfoxide (DMSO) on drug permeation through across the rat abdominal skin. The transdermal patches were prepared by solvent casting method using different amounts and combination of hydroxyl propyl methyl cellulose (HPMC E15), Ethyl cellulose (EC) and Eudragit RS100 (ERS). The drug and excipients compatibility studied by Fourier transform infrared spectroscopy (FTIR). In-vitro drug release studies were studied using dialysis membrane and Ex-vivo skin permeation studies were performed on rat abdominal skin using Franz diffusion cell. Diffused drug was quantified by Uv-Spectrophotometer. The prepared patches were subjected to physicochemical studies such as drug content, weight variation, thickness, moisture absorption, moisture loss, water vapor transmission rate (WVTR) and folding endurance. The prepared films were smooth, flexible, uniform thickness, and content of drug. The FTIR studies indicated that there was no interaction between drug and excipients. Ex-vivo studies showed that as an increasing DMSO concentration to an increased cumulative amount of drug released.