Critically ill children did not benefit from tight glycaemic control.

Study queStion Setting: Thirty-five paediatric intensive care unit (ICU) centres. Patients: Three hundred and sixty patients (median age 5.5 years, IQR 1.4–12.5 years) in the lower target group; 353 patients (median age 6.7 years, IQR 1.7–12.8 years) in the higher target group. Intervention: Randomisation to low target glycaemic control group (80–110 mg/dL (3.3–6.1 mmol/L)) or higher target glycaemic control group (150–180 mg/ dL (8.3–10 mmol/L). Outcomes: Primary outcome: number of ICU-free days to day 28. Prespecified secondary outcomes: 90-day mortality, severity of organ dysfunction, the number of ventilator-free days to day 28, incidence of healthcare-associated infection and incidence of hypoglycaemia. Patient follow-up: Patient was followed up for 90 days. Recruitment stopped at 50% due to low likelihood of benefit and potential of harm. Main reSultS