Focal adhesion kinase is required for IGF - 1 - mediated growth of skeletal 1 muscle cells via a TSC 2 - mTOR - S 6 K 1 - associated pathway
نویسندگان
چکیده
6 MRC-ARUK Centre of Excellence for Musculoskeletal Ageing Research, School of Graduate Entry Medicine and 7 Health, University of Nottingham, Royal Derby Hospital, Derby DE22 3DT, UK; Department of Cellular and 8 Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA; School 9 of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, LE11 3TU. Centre 10 d’Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, 13288 Marseille, France; INSERM, U1104, 11 13288 Marseille, France; CNRS, UMR 7280, 13288 Marseille, France 12 13 14 15 *These authors contributed equally 16 Running Head: FAK and muscle growth 17 Word count: 8322 18 Corresponding Author: Dr Philip J Atherton 19 Tel: +44 (0)1332 724725 20 Email: [email protected] 21 Articles in PresS. Am J Physiol Endocrinol Metab (May 21, 2013). doi:10.1152/ajpendo.00541.2012
منابع مشابه
Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway.
Focal adhesion kinase (FAK) is an attachment complex protein associated with the regulation of muscle mass through as-of-yet unclear mechanisms. We tested whether FAK is functionally important for muscle hypertrophy, with the hypothesis that FAK knockdown (FAK-KD) would impede cell growth associated with a trophic stimulus. C₂C₁₂ skeletal muscle cells harboring FAK-targeted (FAK-KD) or scramble...
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