The binding of 2-acetylaminofluorene to rat liver ribonucleic acid in vivo.

including the potent hepatic carcinogen, 2-acetylamino fluorene (2-AAF), become bound to tissue protein in susceptible animals (6, 20, 35). Recently, it has been reported (18) and confirmed (10, 19, 38) that radioactive 2-AAF also binds to liver ribonucleic acid (RNA) when administered to rats. Because of its possible importance to our understanding of the pathogenesis of liver cancer, some aspects of the nature of the interaction between 2AAF and liver RXA and of its possible significance in the over-all process of carcinogenesis have been studied. The results of this investigation are reported here.