Spitzoid melanoma.
نویسنده
چکیده
Because spitzoid melanoma shares many histopathologic features with Spitz nevus, it is one of the most difficult lesions to diagnose in dermatopathology. Uncertainty exists in the medical literature about how to diagnose melanocytic proliferations including Spitz nevus and spitzoid melanoma. A misdiagnosis of a melanoma as Spitz nevus is one of the most frequent causes of malpractice lawsuits in surgical pathology and dermatopathology. This contribution provides a review of the clinical presentation, histopathology, ancillary studies, treatment, and the differential diagnosis of spitzoid melanoma.
منابع مشابه
BRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance.
BACKGROUND The relationships between so-called spitzoid tumours have proven difficult to understand. OBJECTIVES To address three questions: does spitzoid tumour morphological similarity reflect molecular similarity? Does Spitz naevus progress into spitzoid melanoma? Are ambiguous spitzoid tumours genuine entities? METHODS BRAF, NRAS and HRAS mutations were analysed using single-strand confo...
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Cutaneous melanoma is extremely uncommon in children. Further, Asian-Americans appear to be at decreased risk for cutaneous melanoma. The authors present the case of a prepubescent Asian girl who presents with the rare spitzoid variant of cutaneous melanoma. The patient is a 4-year-old girl of Chinese descent who presented with a red, raised nodule, which increased in size over a 3-month period...
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BACKGROUND Although the majority of melanomas demonstrate high rates of mutations in B-RAF or N-RAS that result in constitutive activation of the mitogen-activated protein kinase-signaling pathway, emerging data suggest molecular differences among melanoma subtypes. In this study, the authors evaluated the contribution of B-RAF and N-RAS mutations to the pathogenesis of Spitzoid melanomas. ME...
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Melanoma is currently the sixth most common cancer in the United States with incidence rates increasing faster than for any other cancer. ii The lifetime risk of developing invasive melanoma in the United States is currently 1 in 71 compared with an estimate of 1 in 600 in 1960. However, despite these rising figures, melanoma of all types in childhood remains uncommon. Children represent 2% of ...
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ورودعنوان ژورنال:
- Clinics in dermatology
دوره 27 6 شماره
صفحات -
تاریخ انتشار 2009