Recent advances in chiral separation principles in capillary electrophoresis and capillary electrochromatography.
نویسندگان
چکیده
This review summarizes recent developments in chiral separation in capillary zone electrophoresis (CZE), electrokinetic chromatography (EKC), and capillary electrochromatography (CEC) covering literature published since the year 2000. New chiral selectors and innovative approaches for CE and CEC are introduced. Recent progress in column technology for CEC is highlighted and the development of new chiral stationary phases is discussed. This review is not dedicated to list applications but will focus on new developments.
منابع مشابه
Development of Chiral Separation Systems for Capillary Electrophoresis, Electrochromatography and Liquid Chromatography
Since the turn of the twentieth century, it has been recognized that many drugs, agrochemicals, food additives and fragrances are chiral compounds and their chirality may considerably affect their bioactive behavior [1, 2]. The demand has been increasing for new analytical methods with high selectivity and efficiency. Chiral separation has become an attractive and important field in the separat...
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A common approach in resolving enantiomers of chiral basic drugs by capillary electrophoresis (CE) is to use cyclodextrins (especially their anionic derivatives) as chiral selector in the acidic buffer (pH ≤ 3) in normal or reversed (carrier) mode. Then, some organic modifiers are added to the buffer solution if the resolution is not satisfactory. In case of cetirizine (CTN), applying the same ...
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ورودعنوان ژورنال:
- Electrophoresis
دوره 25 23-24 شماره
صفحات -
تاریخ انتشار 2004