Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine.
نویسندگان
چکیده
The dual native chemical ligation at lysine strategy was revised by replacing the acid-labile Cbz protecting group with photolabile NVOC at the 4-mercaptolysine side chain. The optimized strategy was subsequently applied to the synthesis of K48-linked diubiquitin.
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 38 شماره
صفحات -
تاریخ انتشار 2010