Circulation: European Perspectives in Cardiology
نویسنده
چکیده
I 2000, Stéphane Germain, BSc, PhD, director of research at the Institut National de la Santé et de la Recherche Médicale (INSERM) and group leader at the Centre for Interdisciplinary Research of the Collège de France in Paris, France, took up an intriguing challenge. During a sabbatical in Boston, MA, his previous boss, Pierre Corvol, MD, PhD (see http://circ.ahajournals. org/content/113/20/f77), who played a key role in the development of drugs acting on the renin-angiotensin system, had been inspired by the discoveries surrounding angiogenesis made by the late Judah Folkman, MD, and molecular biologist Napoleone Ferrara, MD, PhD, among others. Dr Germain explains, “There was great excitement about angiogenesis at that time, and Professor Corvol offered me an empty lab with the challenge, which was quite crazy, in retrospect, to work on angiogenesis. I accepted this rare opportunity to set up a new lab by myself in the great environment of the Collège de France and publish something new in the field within 3 years.” There was no special support or funding. Dr Germain continues, “Taking advantage of techniques I had learnt in Boston, I set up a screen aimed at identifying genes whose expression is upregulated in endothelial cells. We identified roughly 350 genes that were upregulated in endothelial cells, and some of them were unknown. This was exciting. We started by showing that the expression of the angiopoietin-like protein 4 gene (angptl4) is upregulated by hypoxia in endothelial cells in vitro and in vivo.1
منابع مشابه
European Society of Cardiology Working Groups. Working Group 18: Thrombosis. Interview by Emma Wilkinson.
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[1] Pyorala K, De Backer G, Graham I. Poole-Wilson PA, Wood D on behalf of the Task Force. Prevention of coronary heart disease in clinical practice. Recommendations of the Task Force of the European Society of Cardiology, European Atherosclerosis Society and the European Society of Hypertension. Eur Heart J 1994; 15: 1300-31. [2] The Task Force on the Management of Acute Myocardial Infarction ...
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