Magnetic Resonance Spectroscopy and Imaging at 9.4T in P4 rat pup brain following cerebral hypoxia-ischemia

نویسندگان

  • Y. van de Looij
  • A. Chatagner
  • N. Kunz
  • P. S. Hüppi
  • S. V. Sizonenko
  • R. Gruetter
چکیده

Y. van de Looij, A. Chatagner, N. Kunz, P. S. Hüppi, S. V. Sizonenko, and R. Gruetter Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Division of Child Growth & Development, Department of Pediatrics, University of Geneva, Geneva, Switzerland, Departments of Radiology, University of Geneva and University of Lausanne, Geneva and Lausanne, Switzerland

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Longitudinal MR assessment of hypoxic ischemic injury in the immature rat brain.

Extremely preterm infants commonly show brain injury with long-term structural and functional consequences. Three-day-old (P3) rat pups share some similarities in terms of cerebral development with the very preterm infant (born at 24-28 weeks of gestation). The aim of this study was to assess longitudinally the cerebral structural and metabolic changes resulting from a moderate neonatal hypoxic...

متن کامل

Rodent neonatal bilateral carotid artery occlusion with hypoxia mimics human hypoxic-ischemic injury.

We report a new clinically relevant model of neonatal hypoxic-ischemic injury in a 10-day-old rat pup. Bilateral carotid artery occlusion and 8% hypoxia (1 to 15 mins, BCAO-H) was induced with varying degrees of injury (mild, moderate, severe), which was quantified using magnetic resonance imaging including diffusion-weighted and T2-weighted imaging at 24 h and 21/28 days. We developed a magnet...

متن کامل

Neuroprotective effects of crocin on the histopathological alterations following brain ischemia-reperfusion injury in rat

Objective(s): Some histopathological alterations take place in the ischemic regions following brain ischemia. Recent studies have demonstrated some neuroprotective roles of crocin in different models of experimental cerebral ischemia. Here, we investigated the probable neuroprotective effects of crocin on the brain infarction and histopathological changes after transient model of focal cerebral...

متن کامل

Protective Effect of Hypoxic Preconditioning on Hypoxic-Ischemic Injured Newborn Rats

Brief episodes of cerebral hypoxia-ischemia cause transient ischemic tolerance to subsequent ischemic events that are otherwise lethal. This study was conducted to evaluate the protective effect of hypoxic preconditioning on hypoxic-ischemic injury in the neonatal rat and the persistence of a protective window after hypoxic preconditioning. The rats were preconditioned with hypoxia (8% oxygen, ...

متن کامل

Short Erythropoietin treatment following Hypoxia-Ischemia in the immature rat brain: macro-, micro-structural and metabolic assessment using multimodal MR

Introduction: The 3-day old rat (P3) shares some similarities in terms of cortical neuronal, glial and oligodendroglial development to the very preterm infant around 24-28 weeks of gestation. Animal models of preterm brain injury can be achieved by Hypoxia-Ischemia (HI). Erythropoietin (EPO) has been shown to be neuroprotective in different models of preterm brain injury [1] but has not been te...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2007