Influence of Fluctuations in Actin Structure on Myosin V Step Size
نویسنده
چکیده
We study the influence of helical disorder in the actin structure on the myosin V step size, predicted from the elastic lever arm model. We show that fluctuations of +/-5 degrees per actin subunit, as proposed by Egelman et al., significantly alter the distribution of step sizes and improve the agreement with experimental data.
منابع مشابه
Se p 20 05 Influence of fluctuations in actin structure on myosin V step size
Myosin V is a motor protein from the myosin superfamily, involved in various intracellular transport processes [1]. It is a processive motor [2], which means that a single protein molecule can transport cargoes along actin filaments over distances of several micrometers. It is dimeric, consisting of two identical heads, each attached to a lever arm, joined with each other through a tail domain....
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ورودعنوان ژورنال:
- Journal of chemical information and modeling
دوره 45 6 شماره
صفحات -
تاریخ انتشار 2005