Binding and Stable TAP Interaction Molecules Correlates with Restricted Peptide Reduced Cell Surface Expression of HLA-C
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منابع مشابه
TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide
BACKGROUND The human major histocompatibility complex (MHC) class lb molecule HLA-E is transcribed in most tissues but little is known about its localisation within the cell. We have recently shown that HLA-E binds signal-sequence-derived peptides from human MHC class I molecules in vitro. RESULTS Using a newly characterised antibody recognising HLA-E, we show that HLA-E is expressed at the c...
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The transporter associated with antigen processing (TAP) translocates the cytosol-derived proteolytic peptides to the endoplasmic reticulum lumen where they complex with nascent human leukocyte antigen (HLA) class I molecules. Non-functional TAP complexes and viral or tumoral blocking of these transporters leads to reduced HLA class I surface expression and a drastic change in the available pep...
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