Formulation And Evaluation pH Stimuli Sensitive Multiparticulate Delivery System Of Clarithromycin For The Treatment Of Helicobacter pylori
نویسنده
چکیده
pH stimuli sensitive microspheres of clarithromycin were prepared on the principle of cation induced gelification, whereas, sodium alginate and pectin blend were cross linked with calcium chloride and investigated with regard to drug targeting specificity in the gastric mucosa. The microspheres were found to be discrete, spherical, free flowing and of monolithic matrix type. The yields of microspheres were found to varied 65±2 to 76±3%. Prepared microspheres have shown good mucoadhesive efficacy and anti microbial activity against isolated Helicobacter pylori strain. The following repeated oral administration of the formulation to Helicobacter pylori infected Mongolian gerbils was examined by polymerase chain reaction technique. It was found that the coated formulation was more effective than clarithromycin suspension. The results further substantiated that pH sensitive microspheres were found to adhere to the gastric or intestinal mucosa with high affinity might make contribution for complete eradication of Helicobacter pylori.
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Formulation and In-vitro Evaluation of pH-Sensitive Oil Entrapped Polymeric Blend Amoxicillin Beads for the Eradication of Helicobacter pylori
Oral pH sensitive drug delivery systems are of utmost importance as these systems deliver the drug at specific part of the gastrointestine (GI) as per the pH of GI, resulting in improved patient therapeutic efficacy and compliance. The pH range of fluids in various segments of the GI tract may provide environmental stimuli for drug release. The aim of this study was to design buoyant beads c...
متن کاملFormulation and In-vitro Evaluation of pH-Sensitive Oil Entrapped Polymeric Blend Amoxicillin Beads for the Eradication of Helicobacter pylori
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متن کاملFormulation and In-vitro Evaluation of pH-Sensitive Oil Entrapped Polymeric Blend Amoxicillin Beads for the Eradication of Helicobacter pylori
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