Spin models inferred from patient data faithfully describe HIV fitness landscapes and enable rational vaccine design

Karthik Shekhar, 2 Claire F. Ruberman, Andrew L. Ferguson, John P. Barton, 2 Mehran Kardar, ∗ and Arup K. Chakraborty 5, 6, 7, 8, † Department of Chemical Engineering, MIT, Cambridge, MA 02139 Ragon Institute of MGH, MIT and Harvard, Boston, MA 02129 Department of Mathematics, Pomona College, Claremont, CA 91711 Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 Department of Physics, MIT, Cambridge, MA 02139 Department of Chemistry, MIT, Cambridge, MA 02139 Department of Biological Engineering, MIT, Cambridge, MA 02139 Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139