Vigabatrin-associated Visual Field Loss (vavfl): What You Need to Know
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چکیده
منابع مشابه
Evolution of visual field loss over ten years in individuals taking vigabatrin
PURPOSE Vigabatrin-associated visual field loss (VAVFL) occurs in around 45% of exposed people. It is generally accepted that, once established, VAVFL is stable and does not progress with continued VGB use. Most studies have, however, only followed people for short periods. We assessed the evolution of VAVFL over a ten-year period of continued VGB use. METHODS From a group of 201 vigabatrin-e...
متن کاملDetecting vigabatrin toxicity by imaging of the retinal nerve fiber layer.
PURPOSE To quantify retinal nerve fiber layer thickness (RNFLT) and macular thickness (MT) in patients exhibiting vigabatrin-attributed visual field loss (VAVFL) and to determine the efficacy of these measures as markers of the retinal damage associated with vigabatrin. METHODS This was a prospective cross-sectional observational study involving five groups: Group I, 13 patients exhibiting VA...
متن کاملLong term changes in the visual fields of patients with temporal lobe epilepsy using vigabatrin.
AIM To study the long term changes in the concentric contraction of the visual field in patients with temporal lobe epilepsy on vigabatrin medication. METHODS Repeated Goldmann visual field examinations were compared in 27 patients with drug resistant temporal lobe epilepsy and concentric contraction of the visual field. Two groups were studied: 16 patients who had already stopped vigabatrin ...
متن کاملVisual field loss associated with vigabatrin: pathological correlations.
Pathological changes are reported in the anterior visual pathways of a 41 year old man with complex partial seizures treated with vigabatrin who developed bilateral visual field constriction. There was peripheral retinal atrophy with loss of ganglion cells and loss of nerve fibres in the optic nerves, chiasm, and tracts. No evidence of intramyelinic oedema was seen. These findings suggest that ...
متن کاملVisual field defects associated with vigabatrin therapy.
OBJECTIVE To estimate the prevalence of visual field defects in patients taking the anticonvulsant drug vigabatrin and to characterise the features of visual dysfunction found. METHODS Thirty three unselected patients attending neurology and epilepsy clinics were identified as taking vigabatrin and asked to attend for neuro-ophthalmic evaluation. A control group of 16 patients with epilepsy u...
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