CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection.
نویسنده
چکیده
CD40 and CD154 (CD40 ligand) are surface molecules that are central to the cross-talk between T cells and antigen-presenting cells. This article reviews the relevance of CD40-CD154 interaction for regulation of interleukin-12/interferon-gamma production in response to Toxoplasma gondii as an example of an intracellular pathogen. The manner in which defects in CD154 signaling contribute to immunosuppression and susceptibility to opportunistic infections in patients with X-linked hyper IgM syndrome and in patients with human immunodeficiency virus infection is also discussed.
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عنوان ژورنال:
- The Journal of infectious diseases
دوره 185 Suppl 1 شماره
صفحات -
تاریخ انتشار 2002