Formulation, Development and Evaluation of Fast Dissolving Tablet of Salbutamol Sulphate by Using Superdisintegrants of Various Concentrations

Fast dissolving tablets are highly accepted fast growing drug delivery system. This study was aimed at formulation and development of salbutamol sulphate fast dissolving tablet which can dissolve rapidly in the oral cavity. Asthma is a common chronic inflammatory disease of the airways characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Common symptoms include wheezing, coughing, chest tightness, and shortness of breath. Fast dissolving tablets (FDTs) are prepared by several different methods including crystalline transition, phase transition, sublimation, spray drying, and direct compression. Of these approaches, a conventional tablet compression method is used most widely because of its low cost and ease of manufacturing. Fast dissolving Tablets are disintegrating and/or dissolve rapidly in the saliva without the need for water. In the present study, an attempt has been made to prepare fast dissolving tablets of the drug Salbutamol sulphate using superdisintegrants such as Croscarmellose sodium (Ac‐Di‐Sol), Sodium starch glycolate (Explotab) and Crospovidone(polyplasdone XL) by direct compression technique. The prepared tablets were evaluated for hardness, friability, wetting time, weight variation, in vitro disintegration time and in vitro dissolution study. In the present study fast dissolving tablets of salbutamol Sulphate was formulated and evaluated. The formulation Polyplasdone XL Showed the maximum dissolution rate of 99.84% drug release in 10 min. Acdisol containing Tablets released more than 94.33 % of the drug in 10 min and Explotab formulations released more than 93.65% of the drug in 10 min. This shows that the effectiveness of super disintegrants was in the order of polyplasdone XL > Acdisol > Explotab. From the overall observations, formulation F9 containing 6% w/w Polyplasdone XL was considered to be the best formulation, which releases up to 99.84% of the drug in 10 min.