Regulation of Hepcidin and Hemojuvelin Expression and Their Role in Iron Homeostasis
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منابع مشابه
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin.
Mutations in a recently identified gene HJV (also called HFE2, or repulsive guidance molecule C, RgmC) are the major cause of juvenile hemochromatosis (JH). The protein product of HJV, hemojuvelin, contains a C-terminal glycosylphosphatidylinositol anchor, suggesting that it can be present in either a soluble or a cell-associated form. Patients with HJV hemochromatosis have low urinary levels o...
متن کاملRED CELLS Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
Mutations in a recently identified gene HJV (also called HFE2, or repulsive guidance molecule C, RgmC) are the major cause of juvenile hemochromatosis (JH). The protein product of HJV, hemojuvelin, contains a C-terminal glycosylphosphatidylinositol anchor, suggesting that it can be present in either a soluble or a cell-associated form. Patients with HJV hemochromatosis have low urinary levels o...
متن کاملThe Interaction of Alcohol and Iron-Overload in the in-vivo Regulation of Iron Responsive Genes
Patients with alcoholic liver disease (ALD) frequently exhibit iron overload but the molecular mechanisms of alcohol and iron interaction are still unclear. This study investigated the role of alcohol in the regulation of ironresponsive genes, hepcidin, hemojuvelin and leap-2 in both dietary and genetic mouse models. Ethanol significantly down-regulated liver hepcidin and hemojuvelin gene expre...
متن کاملHepcidin downregulation by repeated bleeding is not mediated by soluble hemojuvelin.
Hepcidin is a key regulator of iron homeostasis, while hemojuvelin is an important component of the hepcidin regulation pathway. It has been recently proposed that soluble hemojuvelin, produced from hemojuvelin by the protease furin, decreases hepcidin expression. The aim of the presented study was to examine the downregulation of hepcidin by chronic bleeding in hemojuvelin-mutant mice. Male mi...
متن کاملSkeletal muscle hemojuvelin is dispensable for systemic iron homeostasis.
Hepcidin, a hormone produced mainly by the liver, has been shown to inhibit both intestinal iron absorption and iron release from macrophages. Hemojuvelin, a glycophosphatidyl inositol-linked membrane protein, acts as a bone morphogenetic protein coreceptor to activate hepcidin expression through a SMAD signaling pathway in hepatocytes. In the present study, we show in mice that loss of hemojuv...
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