Pharmacodynamic evaluation of extending the administration time of meropenem using a Monte Carlo simulation.
نویسندگان
چکیده
A Monte Carlo simulation demonstrated that 1 g of meropenem (MEM) every 8 h (q8h) (3-h infusion) has a higher target attainment rate against Pseudomonas aeruginosa than either 500 mg of MEM q8h (3-h infusion) or 0.5 g of imipenem-cilastatin (I-C) q6h (1-h infusion). For other pathogens, 500 mg of MEM q8h was equivalent or superior to I-C.
منابع مشابه
Does prolonged infusion allow lower daily dose of meropenem than bolus dosing?
s of the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy; San Francisco (CA). Washington (DC): American Society for Microbiology; 1993. 6. Lomaestro BM, Drusano GL. Pharmacodynamic evaluation of extending the administration time of meropenem using a Monte Carlo simulation. Antimicrob Agents Chemother 2005;49(1):461-463. 7. Kuti JL, Dandekar PK, Nightingale CH, Nicolau DP. ...
متن کاملApplication of Antimicrobial Pharmacodynamic Concepts into Clinical Practice: Focus on -Lactam Antibiotics Insights from the Society of Infectious Diseases Pharmacists
Thomas P. Lodise, Pharm.D., Ben M. Lomaestro, Pharm.D., and George L. Drusano, M.D. In recent years there have been tremendous strides in understanding the relationship between the pharmacodynamics of -lactams and microbiologic response. For -lactams, in vitro and animal studies suggest that the amount of time in which free or non–protein-bound antimicrobial concentration exceeds the minimum in...
متن کاملMeropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution.
OBJECTIVES To compare the plasma and subcutaneous tissue concentration-time profiles of meropenem administered by intermittent bolus dosing or continuous infusion to critically ill patients with sepsis and without renal dysfunction, and to use population pharmacokinetic modelling and Monte Carlo simulations to assess the cumulative fraction of response (CFR) against Gram-negative pathogens like...
متن کاملMonte Carlo Simulation of Prostate Intensity Modulated Radiotherapy Using PRIMO Software: A Feasibility Study
Introduction: Nowadays Intensity Modulated Radiotherapy (IMRT) is a common method for treating prostate cancers. Must of the Monte Carlo software cannot simulate the IMRT procedures due to inability of these soft wares to simulate the multi leaf collimator (MLC) positions or movements. A new user-friendly software based on the PENELOPE Monte Carlo code named PRIMO was published...
متن کاملLoss of Load Expectation Assessment in Deregulated Power Systems Using Monte Carlo Simulation and Intelligent Systems
Deregulation policy has caused some changes in the concepts of power systems reliability assessment and enhancement. In this paper, generation reliability is considered, and a method for its assessment using intelligent systems is proposed. Also, because of power market and generators’ forced outages stochastic behavior, Monte Carlo Simulation is used for reliability evaluation. Generation r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 49 1 شماره
صفحات -
تاریخ انتشار 2005