Thomson ReuTeRs scienTific soluTions: idenTifying biomaRkeRs of muscaRinic
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چکیده
The muscarinic acetylcholine M1 receptor protein is known to play a role in hippocampal-based and shortterm memory. It has been shown to improve cognition and modify Alzheimer’s disease (AD) properties in animal models. As a result, muscarinic M1 agonism has been identified as a target for AD treatment. Initial drug development programs targeting the muscarinic M1 receptor were curtailed by unacceptable adverse events due to a lack of specificity for the M1 subtype. More recent research has focused on allosteric agonists which have greater M1 receptor specificity. As these compounds start to move into clinical development, there is a need for biomarkers of M1 agonism to help speed up their development. INTRODUCTION TO SOLUTIONS Using Thomson Reuters Integrity and MetaCore, we investigate known markers of muscarinic M1 agonism, identify potential new biomarkers and assess their suitability for further validation and use in clinical trials.
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تاریخ انتشار 2013