Contraction-driven cell motility.

نویسندگان

  • P Recho
  • T Putelat
  • L Truskinovsky
چکیده

We propose a mechanism for the initiation of cell motility that is based on myosin-induced contraction and does not require actin polymerization. The translocation of a cell is induced by symmetry breaking of the motor-driven flow, and the ensuing asymmetry gives rise to a steady motion of the center of mass of a cell. The predictions of the model are consistent with observations on keratocytes.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Autotaxis as a mechanism of cell polarization and motility

We propose a mechanism of cell motility which places emphasis on contraction while ignoring treadmilling. At the basis of the model is contraction driven uphill diffusion destabilizing symmetric configuration and causing polarization. The morphological instability is due to spontaneous internal motion of the cytoskeleton which is generated by active cross-linkers and simultaneously transports t...

متن کامل

Mechanotaxis and cell motility

We propose a mechanism of cell motility which is based on contraction and does not require protrusion. The contraction driven translocation of a cell is due to internal flow of the cytoskeleton generated by molecular motors. Each motor contributes to the stress field and simultaneously undergoes biased random motion in the direction of a higher value of this stress. In this way active cross-lin...

متن کامل

Actomyosin contraction induces droplet motility

While cell crawling on a solid surface is relatively well understood, and relies on substrate adhesion, some cells can also swim in the bulk, through mechanisms that are still largely unclear. Here, we propose a minimal model for in-bulk self-motility of a droplet containing an isotropic and compressible contractile gel, representing a cell extract containing a disordered actomyosin network. In...

متن کامل

The size, shape, and dynamics of cellular blebs

A cellular bleb grows when a portion of the cell membrane detaches from the underlying cortex under the influence of a cytoplasmic pressure. We develop a quantitative model for the growth and dynamics of these objects in a simple two-dimensional setting. In particular, we first find the minimum cytoplasmic pressure and minimum unsupported membrane length for a stationary bleb to nucleate and gr...

متن کامل

Redundant mechanisms for stable cell locomotion revealed by minimal models.

Crawling of eukaryotic cells on flat surfaces is underlain by the protrusion of the actin network, the contractile activity of myosin II motors, and graded adhesion to the substrate regulated by complex biochemical networks. Some crawling cells, such as fish keratocytes, maintain a roughly constant shape and velocity. Here we use moving-boundary simulations to explore four different minimal mec...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Physical review letters

دوره 111 10  شماره 

صفحات  -

تاریخ انتشار 2013