CuI catalyzed N-arylation of amide as a key step for the preparation of 3-aryl beta-carbolin-1-ones.
نویسندگان
چکیده
An expedient synthetic route for 3-aryl beta-carbolin-1-ones was developed starting from ethyl acetamidocyanoacetate and chalcone derivatives. The five- and six-membered nitrogen-containing rings in the beta-carbolin-1-ones were elaborated efficiently by an intramolecular ketone-nitrile annulation and an intramolecular N-arylation of amide respectively.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 2 11 شماره
صفحات -
تاریخ انتشار 2004