Pkcε Dependent and Independent Effects of Taurolithocholate on 1 Pi3k/pkb Pathway and Taurocholate Uptake in Huh-ntcp Cell Line
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چکیده
1 PI3K/PKB PATHWAY AND TAUROCHOLATE UPTAKE IN HUH-NTCP CELL LINE 2 3 Christopher M. Schonhoff, Ai Yamazaki, Simon Hohenester, Cynthia R.L. Webster, 4 Bernard Bouscarel, M. Sawkat Anwer 5 6 Departments of Biomedical and Clinical Sciences, Tufts Cummings School of 7 Veterinary Medicine North Grafton, Massachusetts; Medicine II, University of Munich 8 Medical Center, Munich, Germany; Gastroenterology Research Laboratory, George 9 Washington University, Washington, DC. 10 11 Running head: nPKCε mediated effects of TLC 12 13 Corresponding author address: 14 M. Sawkat Anwer 15 Department of Biomedical Sciences 16 Tufts Cummings School of Veterinary Medicine 17 200 Westboro Road 18 N Grafton, MA 01536 19 [email protected] 20 Phone: 508-839-8788 Fax: 508-839-8787 21 22 23 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (October 8, 2009). doi:10.1152/ajpgi.00177.2009
منابع مشابه
Mechanism of inhibition of taurolithocholate‐induced retrieval of plasma membrane MRP2 by cyclic AMP and tauroursodeoxycholate
Taurolithocholate (TLC) produces cholestasis by inhibiting biliary solute secretion in part by retrieving MRP2 from the plasma membrane (PM). Tauroursodeoxycholate (TUDC) and cAMP reverse TLC-induced cholestasis by inhibiting TLC-induced retrieval of MRP2. However, cellular mechanisms for this reversal are incompletely understood. Recently, we reported that TLC decreases PM-MRP2 by activating P...
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Webster, Cynthia R. L., and M. Sawkat Anwer. Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G1165–G1172, 1999.—cAMP stimulates Na1-taurocholate (TC) cotransport by translocating the Na1TC-cotransporting peptide (Ntcp) to the plasma membrane. The present study was undertaken to determine whether the ...
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