Antioxidant enzymes activity in subjects with Parkinson’s disease under L-DOPA therapy
نویسنده
چکیده
1Elena C. Crăciun, 2Eleonora Dronca, 3Nicoleta V. Leach 1 Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2 Department of Molecular Sciences, Faculty of Medicine, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 4 Vth Department of Internal Medicine, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania.
منابع مشابه
Recent advances in pharmacological therapy of Parkinson’s disease: Levodopa and carbidopa protective effects against DNA oxidative damage
Parkinson’s disease is one of the most common progressive neurodegenerative disorder. It is characterized by the depletion of dopamine in the dopaminergic neurons of the striatum of the brain. Pharmacological treatment involves the administration of a dopamine precursor, levodopa (L-Dopa), which crosses the blood-brain barrier and replaces the loss of dopamine in the brain. One of the main draw...
متن کاملThe Effect of Olive Leaf Methanolic Extract on Hippocampal Antioxidant Biomarkers in an Animal Model of Parkinson’s Disease
Background and Objective: Parkinson’s disease (PD) is a chronic neurodegenerative disease characterized by damages to striatal dopaminergic neurons that affects 1 to 2% of the population above 65 years of age. Olive leaf extract (OLE) is a powerful antioxidant that is considered as a source of various phenolic compounds. This study was conducted to evaluate the effects of methanolic OLE on hipp...
متن کاملThe antioxidant effect of hesperetin and nano-hesperetin on activity of catalase and superoxide dismutase enzymes in the hippocampus of animal model of Parkinson's disease
Background and objectives: Hesperetin flavanone is a natural bioflavonoid found abundantly in citrus fruits with antioxidant and anti-inflammatory properties. Nano sizing techniques improve the bioavailability of poorly soluble drugs such as hesperetin. Main feature of Parkinson's disease is the degeneration of dopaminergic neurons in the substantia nigra. The rate of oxidative...
متن کاملAmelioration of CNS Toxicities of L-Dopa in Experimental Models of Parkinson’s disease by Concurrent Treatment with Tinospora cordifolia
Parkinson’s disease is the second most common neurodegenerative disease, primarily affecting people of ages over 45-55 years, although young adults and even children can also be affected. The gold standard drug for the treatment of Parkinson’s disease is L-DOPA, but various studies have proved that the treatment with L-DOPA leads to the death of surviving dopaminergic neurons in the CNS. Hence ...
متن کاملEffects of seed inoculation by cycocel and biofertilizers on yield, antioxidant enzymes activity and some biochemical traits of wheat (Triticum aestivum L.) under soil salinity condition
In order to study the effects of seed inoculation by cycocel and biofertilizers on yield, antioxidant enzymes activity and some biochemical traits of wheat (Triticum aestivum L.) under soil salinity condition, a factorial experiment was conducted based on randomized complete block design with three replications in a research greenhouse of Faculty of Agriculture and Natural Resources, University...
متن کامل