Pharmacologyonline 2: 416-429 (2010) Newsletter Tzankova and Mitcheva
نویسندگان
چکیده
The mechanisms of adverse drug reactions in children have been often related to the differences in patient response on pharmacokinetic level. Age-dependent variability in drug metabolizing enzyme systems (DMES) contributes to the wide range of drug responses observed in children. This review provides background information on a variety of DMES in biotransformation phase I and phase II that can vary as a function of developmental stage. The ontology of metabolizing systems is described via reference to pediatric studies involving therapeutic drugs and evidence from in vitro enzyme studies. The finding that drug response can be influenced by developmental profile of DMES has offered great hope for realizing patient-specific targeted therapy and approach to decrease adverse drug reactions. Prevention requires clinical monitoring in pediatric population.
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