Electrochemical determination of the antidiabetic drug repaglinide.
نویسندگان
چکیده
The electrochemical oxidation of repaglinide has been carried out in Britton-Robinson buffer at carbon paste and glassy carbon electrodes. Repaglinide exhibits a well-defined irreversible oxidation peak over the entire pH range (2-11). Differential pulse voltammetry was used to determine repaglinide in pure form. The peak current varied linearly in the following ranges: 8.0 x 10(-7)-3.2 x 10(-6) M and 4.0 x 10(-7)-4.0 x 10(-6) M in case of carbon paste electrode and glassy carbon electrode, respectively. In case of carbon paste electrode the limits of detection (LOD) and quantification (LOQ) were 1.348 x 10(-7) M and 4.494 x 10(-7) M, respectively. For glassy carbon electrode the LOD and LOQ were 1.062 x 10(-7) M and 3.54 x 10(-7) M, respectively. The percentage recoveries were found in the following ranges: 99.09-100.07% and 99.0-100.50% for carbon paste electrode and glassy carbon electrode, respectively. The relative standard deviations were found in the following ranges: 0.636-1.395% and 0.431-1.104% in case of carbon paste electrode and glassy carbon electrode, respectively. Differential pulse voltammetry was successfully applied for the determination of repaglinide in tablets and human serum.
منابع مشابه
Comparison of UV spectrophotometry and high performance liquid chromatography methods for the determination of repaglinide in tablets
BACKGROUND Repaglinide is a miglitinide class of antidiabetic drug used for the treatment of type 2 diabetes mellitus. A fast and reliable method for the determination of repaglinide was highly desirable to support formulation screening and quality control. OBJECTIVE UV spectrophotometric and reversed-phase high performance liquid chromatography (RP-HPLC) methods were developed for determinat...
متن کاملPharmacokinetic Interactions Affecting the Antidiabetic Repaglinide
I N T R O D U C T I O N ..........................................................................11 R E V I E W O F T H E L I T E R A T U R E ............................................12 1 Drug interactions .............................................................................12 1.1 Pharmacokinetic drug interactions ............................................12 1.2 Pharmacodynamic dr...
متن کاملSafety and efficacy of repaglinide in type 2 diabetic patients with and without impaired renal function.
OBJECTIVE To evaluate the influence of renal impairment on the safety and efficacy of repaglinide in type 2 diabetic patients. RESEARCH DESIGN AND METHODS This multinational, open-label study comprised a 6-week run-in period, continuing prestudy antidiabetic medication, followed by a titration period (1-4 weeks) and a 3-month maintenance period. Patients with normal renal function (n = 151) a...
متن کاملInteraction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.
OBJECTIVE The uptake of drugs into hepatocytes is a key determinant for hepatic metabolism, intrahepatic action, their subsequent systemic plasma concentrations, and extrahepatic actions. In vitro and in vivo studies indicate that many drugs used for treatment of cardiovascular diseases (e.g., oral antidiabetic drugs, statins) are taken up into hepatocytes by distinct organic anion transporters...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
دوره 128 1 شماره
صفحات -
تاریخ انتشار 2008