Effect of Alkaloid Extract of Phyllanthus Niruri on Rabbits Infected with Enteropathogenic Escherichia Coli

Five groups of six rabbits each were infected with 10 6 cell/ml inoculums of “enteropathogenic” Escherichia coli and treated with alkaloid extract of Phyllanthus niruri administered as strawberry at 100mg/day divided in four doses. Sample of serum and urine were collected before infection, 26hr after infection, 3 rd day of therapy (72hr) and 48hr after 7 th day of therapy. Creatinine, urea nitrogen, aspartate transaminase, alanine transaminase packed cell volume, total white blood cell count, polymorphornuclear neutrophils, lymphocytes and levels of hemoglobin were analyzed in serum while alkaloid concentration were analyzed in both samples. There were no changes in enzymes concentration. A decrease in PCV, hemoglobin lymphocytes and an increase in TWBC and neutrophils were noticed. Alkaloid was well tolerated and showed a great promise in therapy.