Out-patient treatment of ulcerative colitis. Comparison between three doses of oral prednisone.
نویسندگان
چکیده
The efficacy of corticosteroids in the treatment of ulcerative colitis has been established (Truelove and Witts, 1955), but the optimum dose has been less thoroughly studied. In a comparative trial of different methods of treatment Truelove (1960) reported a remission rate of 35% in out-patients using prednisolone 20 mg. daily, and Watkinson (1961a, 1961b) observed remission in 12 out of 36 patients given the same dose of prednisone. However, using a larger dose of prednisone in two outpatient trials, a remission rate of 650% was obtained at this clinic (Lennard-Jones, Longmore, Newell, Wilson, and Avery Jones, 1-960). The present study was therefore undertaken to compare the results of using 60, 40, and 20 mg. of prednisone daily as treatment for active ulcerative colitis.
منابع مشابه
An assessment of prednisone, salazopyrin, and topical hydrocortisone hemisuccinate used as out-patient treatment for ulcerative colitis.
Two consecutive trials of out-patient treatment for mild cases of active ulcerative colitis are described. In the first trial oral prednisone gave significantly better results than a placebo. In the second trial "salazopyrin" gave final results approaching those of prednisone, although over a longer time and with a higher incidence of unpleasant side-effects, but topical hydrocortisone gave dis...
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Two consecutive trials of out-patient treatment for mild cases of active ulcerative colitis are described. In the first trial oral prednisone gave significantly better results than a placebo. In the second trial "salazopyrin" gave final results approaching those of prednisone, although over a longer time and with a higher incidence of unpleasant side-effects, but topical hydrocortisone gave dis...
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Dear Sir, Ulcerative colitis is a disease of unknown etiology with an intermittent clinical course and irregular response to the therapy. In the last few years, some authors have suggested that ulcerative colitis should be considered as an autoimmune disease. In fact, immunosuppres-sive therapy has been used as treatment although without definitive results [1, 2]. We present a patient with a ca...
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ورودعنوان ژورنال:
- British medical journal
دوره 2 5302 شماره
صفحات -
تاریخ انتشار 1962