Onl_Er_jah3_1055 1..12

نویسندگان

  • Andrea Protti
  • Xuebin Dong
  • Silvia Lorrio
  • David Onthank
  • Ajay M. Shah
  • Rene M. Botnar
چکیده

Background-—Well-defined inflammation, proliferation, and maturation phases orchestrate the remodeling of the injured myocardium after myocardial infarction (MI) by controlling the formation of new extracellular matrix. The extracellular matrix consists mainly of collagen but also fractions of elastin. It is thought that elastin is responsible for maintaining elastic properties of the myocardium, thus reducing the risk of premature rupture. An elastin/tropoelastin–specific contrast agent (Gd-ESMA) was used to image tropoelastin and mature elastin fibers for in vivo assessment of extracellular matrix remodeling post-MI.

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تاریخ انتشار 2015